Synaptotagmin-mediated vesicle fusion regulates cell migration
نویسندگان
چکیده
منابع مشابه
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion
The synaptic vesicle protein synaptotagmin I (syt) promotes exocytosis via its ability to penetrate membranes in response to binding Ca(2+) and through direct interactions with SNARE proteins. However, studies using full-length (FL) membrane-embedded syt in reconstituted fusion assays have yielded conflicting results, including a lack of effect, or even inhibition of fusion, by Ca(2+). In this ...
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Synaptotagmin (syt) 1 is localized to synaptic vesicles, binds Ca2+, and regulates neuronal exocytosis. Syt 1 harbors two Ca2+-binding motifs referred to as C2A and C2B. In this study we examine the function of the isolated C2 domains of Syt 1 using a reconstituted, SNARE (soluble N-ethylmaleimide-sensitive factor attachment receptor)-mediated, fusion assay. We report that inclusion of phosphat...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2010
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.1878